Trioxsalen Topical Solution USP

Trioxsalen Topical Solution USP

Trioxsalen is a type of medicine that falls in the category of ‘photosensitizer’, and they are applied in the management of psoriasis and vitiligo. Psoriasis is a skin disease that presents as red, itchy, scaly plaques, commonly occurring on the elbows, knees, trunk, and scalp. Vitiligo is a disease in which the pigment cells of the skin (melanocytes) are lost. This leads to patches of color change in various parts of the body, such as skin, hair, and mucous membranes.

Trioxsalen has “trioxsalen,” a photosensitizing drug taken with UV-A light. In psoriasis, it decreases the excess production of skin cells. In vitiligo, it stimulates specific skin cells (melanocytes) and re-pigments the patches of white, discolored skin.

Medical Benefits:-

Trioxsalen is a group of drugs known as ‘photosensitizers’ taken in combination with UV-A light. The drug is applied in the treatment of psoriasis and vitiligo. In psoriasis, it decreases the excessive growth of skin cells. In vitiligo, it stimulates some of the skin cells (melanocytes) and re-pigments the patches of white, discolored skin. It is also employed in the treatment of seborrhea (a popular skin condition that produces a red, itching rash and white scales. When occurring on the scalp, it is referred to as dandruff) and ichthyosis (a genetic skin disease in which dead skin cells pile up in thick, dry scales on your skin’s surface).

How Does Trioxasalen work?

Trioxsalen is a class of drugs known as psoralens (ultraviolet light-absorbing and ultraviolet-like acting photosensitizing agents). Methoxsalen changes the manner of skin cell acceptance of ultraviolet light A radiation, thereby removing the disease.

Side Effects:-

• Dizziness
• Blistering and peeling of skin
• Itching of skin
• Reddened and sore skin
• Nausea
• Swelling of feet or lower legs

Precautions:-

• Trioxsalen is a very potent medication that will make your skin more sensitive to the sun. Don’t use it for sun tanning or to build up tolerance to the sun; if you must, don’t use trioxsalen for more than 14 days.
• Trioxsalen and UVA treatments may be administered two or three times a week, at least forty-eight hours apart.
• Take this drug with food or milk, 2-4 hours before your UVA light treatment.
• Do not sunbathe twenty-four (24) hours before trioxsalen application. Use UVA-absorbing, wrap-around sunglasses and cover exposed skin or apply a sunblock (SP 15 or greater) for twenty-four (24) hours before trioxsalen treatment.
• Use extreme care for a minimum of 48 hours following each treatment. Following each treatment, protect your skin for a minimum of 8 hours by using protective clothing.
• Do not raise the amount of methoxsalen topical if you are or will be out in the sun or under an ultraviolet lamp for extended periods.
• Do not drive or use machinery since trioxsalen can cause dizziness.

Frequently Asked Questions(FAQ):-

Q. What is Trioxsalen used for?

Trioxsalen is applied in the management of psoriasis and vitiligo.

Q. How does Trioxsalen act?

Trioxsalen in psoriasis, acts by lowering the excess growth of skin cells. In vitiligo, it stimulates specific skin cells (melanocytes) and facilitates re-pigmentation of the white, depigmented patches.

Q. Under which conditions should I not use Trioxsalen?

Trioxsalen must be administered cautiously to those patients suffering from allergy to sunlight, porphyria, cardiovascular disease, liver disorders, gastric disorders, cataracts, skin cancer, and lupus erythematosus disorder.

Q. Can vision disorders be caused by Trioxsalen?

Yes, Trioxsalen can cause vision disorders. To tackle vision disorders, visit your eye doctor at intervals.